Quelle: https://edlguetl.de/gut-essen     Gute Küche und Essenszubereitung ohne allem, aber mit Herz! Dann muss es doch schmecken, oder…….? Dann guten Appetit.

Source: https://edlguetl.de/gut-essen     Good cuisine and food preparation without everything, but with heart! Then it must taste good, right.......? Then bon appétit.

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Press Releases - Media / Presse- und Medienberichte

Detective: Newsletter 2# - July 2025: DETECTION OF NGT PRODUCTS TO PROMOTE INNOVATION IN THE EUROPEAN UNION

https://0ikuk.mjt.lu/nl3/d0Sk7LteDKjGGu25C74UFw?m=AUUAAHRoPBQAAchrs24AAjSYc98AAYCsLQ0Ana15ACFEdABoehQu4aTzESD9Sg6B0MeJWfvDmgAfSYA&b=abd491b7&e=bbbaa7c2&x=aMAa54hkeEfZjn5I14ZCUN3J5h6JGQz4g8D3o0M5yW4

An Open Letter to Representatives of the European Parliament, the Council of the European Union, and the European Commission

on why Intellectual Property is a catalyst for bringing in agricultural innovation in the EU

https://agriculture.basf.com/dam/jcr:66e33cd8-f4a4-4821-95a4-fa8b502ec874/Open%20letter%20on%20why%20IP%20is%20a%20catalyst%20for%20bringing%20in%20agricultural%20innovation%20in%20the%20EU-%20July%202025.pdf

Wolff K.: EU regulation on plants from new genomic techniques: green shoots of progress?

https://www.managingip.com/article/2f2ucenjczxsplx8n5r7k/sponsored-content/eu-regulation-on-plants-from-new-genomic-techniques-green-shoots-of-progress

Matzk A., Bockholt K.: Genome Editing weltweit: Diese Pflanzen sind schon auf dem Feld

https://www.agrarheute.com/pflanze/getreide/genome-editing-weltweit-diese-gezuechteten-pflanzen-schon-feld-635533

Gentechnik: Dänischer EU-Ratsvorsitz will Lockerungen vorantreiben

https://www.epochtimes.de/politik/ausland/gentechnik-daenischer-eu-ratsvorsitz-will-lockerungen-vorantreiben-a5189926.html

DeGaetano E.: Denmark’s vision for EU agriculture is firmly focused on simplicity

https://www.euractiv.com/section/agriculture-food/news/denmarks-vision-for-eu-agriculture-is-firmly-focused-on-simplicity/

Miller H.I. Bird flu? Don't worry, we fired the scientists!

 https://henrymillermd.org/28715/bird-flu-dont-worry-we-fired-the-scientists

Europabio: ANNUAL REPORT - July 2025

https://www.europabio.org/wp-content/uploads/2025/07/FINAL-EuropaBio-Annual-Report-2025.pdf

Only some selected press releases or media reports are listed here. The daily up-date of the press releases and

media reports are ►here: July, week 29

Publications – Publikationen

Koch M, DeMond J, Pence MG, Schaefer EA, Rudgers G (2025): One risk assessment for genetically modified plants.

Front. Bioeng. Biotechnol. 13:1619857 | https://doi.org/10.3389/fbioe.2025.1619857

With over 30 years’ experience conducting risk assessments for genetically modified (GM) plants, regulatory agencies that review the safety of GM plants understand the potential food, feed, and environmental risks associated with these products. This vast regulatory experience is underutilized when risk assessments for GM plants are repeated on a per-country basis. The redundancy in country-by-country reviews of the same GM plants places a disproportionate regulatory burden on developers and strains limited government resources for conducting safety reviews. Requiring repeated, multi-country risk assessments to obtain food and feed import permits or cultivation permits for GM plants is unnecessary as repeated assessments do not change the safety and associated risks of already approved products. To avoid redundancies in the regulation of GM plants, we propose adoption of one, global risk assessment for food, feed, and environmental release carried out to international standards. Our proposed model for one global risk assessment encourages the sharing of food, feed and environmental risk assessment summaries between countries while maintaining national approvals for GM plants. Steps towards a streamlined and efficient review process for GM plants are discussed, including implementing a global, forward-looking approval process that eliminates repetitive risk assessments and re-reviews of low-risk traits. Harmonization of risk assessment is an achievable goal that would accelerate regulatory approvals and enable broader access to the benefits of GM plants which are currently only available to some countries.

https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1619857/full

Leong, R., He, X., Beijen, B.S. et al. (2025): Unlocking gene regulatory networks for crop resilience and sustainable

agriculture. Nat Biotechnol | https://doi.org/10.1038/s41587-025-02727-4

Understanding the complex mechanisms of gene regulatory networks (GRNs) has emerged as a transformative approach in agricultural research. By deciphering the regulatory mechanisms underlying key traits, GRN studies offer opportunities to enhance crop resilience to environmental challenges, improve yield and ensure sustainable food production. In this Review, we highlight the importance of GRN research in agriculture and explore how cutting-edge biotechnology, interdisciplinary approaches and computational modeling techniques are addressing the challenges in the field. We discuss how integrating diverse datasets at different resolutions empowers us to unravel the complex genetic networks governing crop responses to climate change, pests and diseases. By harnessing the power of GRNs, we have the potential to transform crop improvement strategies, develop stress-tolerant varieties and ensure global food security. We provide insights into the current opportunities and challenges of GRN research in agriculture, bridging the gap between scientific advancements and the pressing need for sustainable agricultural practices.

https://www.nature.com/articles/s41587-025-02727-4

Pal, S., Krishna, R., Dedhia, L. et al. (2025): CRISPR mediated gene editing for economically important traits in horticultural

crops: progress and prospects. Transgenic Res 34, 26 | https://doi.org/10.1007/s11248-025-00444-x

Horticultural crops, with their cost-effectiveness, rich mineral and vitamin content, and high yield potential, have become indispensable worldwide for ensuring food and nutritional security. With the world’s population on the rise and climate change becoming more prominent, it is crucial to focus on creating resilient, high-yielding crop varieties that can withstand the changing climate. Genetic improvement of different horticultural crops using conventional tools is both time-consuming and labourious. However, the breeding period can be cut short by adopting modern breeding techniques, including CRISPR/Cas-mediated genome editing. In the present review, we discuss the progress made so far through genome editing to improve several horticultural crops for various traits like stress resistance, morphology, nutritional attributes, quality, shelf life, male sterility, architecture and economic yield. We have also discussed the emerging CRISPR technologies like base editing, epigenome editing, CRE editing, transposon-based editing, prime editing etc., along with their pros and cons and the future prospects. The ethical considerations for commercialization and current regulatory frameworks for gene-edited products have also been discussed.

https://link.springer.com/article/10.1007/s11248-025-00444-x

Lanzoni, A., Bosi, S., Bregola, V. et al. (2025): Dietary effects of transgenic MON810 Bt-maize pollen on fitness of

Hippodamia variegata Goeze. Arthropod-Plant Interactions 19, 54 | https://doi.org/10.1007/s11829-025-10161-1

Plant food such as pollen represents part of the diet of many predaceous coccinellids, exploited as a supplemental food source when prey is scarce. They can therefore suffer adverse effects when foraging on genetically modified plants expressing Cry1Ab toxin derived from Bacillus thuringiensis Berliner. The Variegated Lady Beetle, Hippodamia variegata Goeze, a very common and important aphid predator in the Mediterranean area, feeds preferably on aphids but can use plant pollen as a supplemental food source. Hence, it can be exposed to Cry proteins when foraging on insect-resistant Bt-maize. In the current study, an experimental methodology to provide pollen to the coccinellids and quantify the amount of pollen eaten was developed. Using this methodology, the potential effects of the consumption of Bt-maize pollen on the fitness of H. variegata were evaluated. Both standardized laboratory bioassays and demographic approach by means of an age-structured matrix population model were performed. Both biological and demographic parameters did not differ between coccinellids fed Bt- or non-Bt-maize pollen. However, demographic analyses showed that some effects of Bt pollen exposure on H. variegata occurred. Indeed, the Bt-pollen-fed females had a higher expected lifetime reproduction; however, a reduced life expectancy occurred early in life for their offspring. As a result, the consumption of Bt-maize pollen causes a lower increase in H. variegata population since a reduction of offspring survival seems only partially outweighed by increased female fecundity. Overall, this study shows that the consumption of Bt-maize pollen expressing Cry1Ab by adults of H. variegata does not significantly affect their fitness, but it also shows that this outcome is a result of a trade-off among vital rates such as age-specific fecundity and survival probability that are positively or negatively influenced. Moreover, the methodology proposed in this study provides a sound exposure system to supply pollen to the coccinellids and appears functional to quantify maize pollen consumption by H. variegata adults

https://link.springer.com/article/10.1007/s11829-025-10161-1

Lakhani, H., Kumar, N., Jangra, A. et al. (2025): Streamlined protoplast transfection system for in-vivo validation and

transgene-free genome editing in Banana. Transgenic Res 34, 28 | https://doi.org/10.1007/s11248-025-00446-9

The advancement in the CRISPR/Cas system has significantly streamlined genome editing in plants, rendering it simple, reliable, and efficient. However, the development of transgene-free crops is a challenging task for vegetatively propagated plants like banana. In the present study, we established banana protoplasts-based versatile and efficient platform for genome editing to overcome this limitation. Herein, a protocol has been optimized for protoplast isolation by considering leaf and embryogenic cell suspension (ECS) of banana cultivar Grand Naine. Freshly prepared ECS was identified as the best source for protoplast isolation. The protoplast viability and competency were checked by transfection with plasmid and RNP complex. Polyethylene glycol (PEG)-mediated protoplast transfection using pCAMBIA1302 and pJL50TRBO vectors showed GFP expression with 30 and 70% efficiency, respectively, eventually proving the protocol’s efficacy. Further, gRNAs targeting banana β-carotene hydroxylase gene are validated by in-vitro cleavage test and subsequently used for RNP complex formation with varied ratios (1:1, 1:2, 1:5, and 1:10) of SpCas9 to gRNA1. Among these, a 1:2 molar ratio proved best to generate indel frequency with 7%. Sequencing analysis of the target amplicon revealed mutations upstream of the PAM region, specifically with gRNA1, among the three in-vitro validated gRNAs. This study evaluated the effectiveness of gRNAs in-vitro and in-vivo, yielding inconsistent results that highlight the need for comprehensive in-vivo validation of their functionality. Conclusively, the optimized protocol for banana transfection has the potential to be harnessed for the generation of transgene-free genetically improved banana. https://link.springer.com/article/10.1007/s11248-025-00446-9

Commentary: Going bananas: how transgene-free editing is contributing to a fruitful future

https://nph.onlinelibrary.wiley.com/doi/am-pdf/10.1111/nph.70150

Ille K., Melzer S. (2025): Efficient and versatile rapeseed transformation for new breeding technologies.

Plant J, 123: e70330 | https://doi.org/10.1111/tpj.70330

Many gene functions are widely studied and understood in Arabidopsis; however, the lack of efficient transformation systems often limits the application and verification of this knowledge in crop plants. Brassica napus L., a member of the Brassicaceae family, is usually transformed by Agrobacterium-mediated hypocotyl transformation, but not all growth types are equally amenable to transformation. In particular, winter rapeseed, which requires vernalization to initiate flowering, is recalcitrant to in vitro regeneration and transformation. The analysis of gene functions in rapeseed is further complicated by the allotetraploid nature of its genome and the genome triplication within the Brassica genus, which has led to the presence of a large number of gene homologs for each Arabidopsis ortholog. We have established a transformation method that facilitates the regeneration of winter rapeseed by using the WUSCHEL gene from Beta vulgaris. This allowed us to efficiently transform a winter and spring rapeseed genotype in small-scale experiments. As proof of principle, we targeted BnCLV3 and BnSPL9/15 with CRISPR/Cas9 and showed that entire gene families are effectively edited using this transformation protocol. This allowed us to simultaneously study many redundantly acting homologous genes in rapeseed. We observed mutant phenotypes for BnCLV3 and BnSPL9/15 in primary transformants, indicating that biallelic knockouts were obtained for up to eight genes. This allowed an initial phenotypic characterization to be performed already a few months after starting the experiment.

https://onlinelibrary.wiley.com/doi/10.1111/tpj.70330

Khazaei, H. and Zanotto, S. (2025): Genomics Enabled Accelerated Faba Bean Improvement for Reduced Anti-nutritional

Factors https://ssrn.com/abstract=5324784 or http://dx.doi.org/10.2139/ssrn.5324784

Faba bean seeds are a rich source of protein, starch, dietary fiber, and micronutrients, making this crop a valuable resource for food and feed worldwide. However, faba bean seeds contain anti-nutritional factors (ANFs), which can limit their dietary value for both food and feed applications. Although ANFs can be reduced or removed through processing, breeding faba bean cultivars with low ANFs remains the most sustainable and effective approach. Here, we discuss the genetic improvements of the main ANFs in faba bean seeds, condensed tannins (CTs) and vicine-convicine (v-c), which have limited their application in food and feed ingredients. The inheritance of low CTs and low v-c content are controlled in a Mendelian recessive manner, and both have been well studied. In recent years, significant progress in the development of genetic and genomic resources has enhanced our understanding of the genes and pathways controlling these traits, thereby accelerating faba bean breeding efforts for low CTs and particularly low v-c cultivars. However, our understanding of other seed ANFs in faba bean – such as phytates, raffinose family oligosaccharides, saponins, lectins, and protease inhibitors – remains largely limited. The recent release of faba bean reference genomes, along with comparative genomics approaches and advances in new breeding technologies such as gene editing, has the potential to accelerate the development of improved faba bean cultivars with reduced levels of less explored seed ANFs.

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5324784

de Andrés-Sánchez J., Puelles-Gallo ., Souto-Romero M., Arias-Oliva M. (2025): Drivers of genetically modified food acceptance

in members of generations Z and Y: Insights from a theory of planned behavior framework.  Food and Humanity 5, 100703   https://doi.org/10.1016/j.foohum.2025.100703

Genetically modified food (GMF), which emerged in the mid-1990s, have enabled the development of more affordable, sustainable products with enhanced characteristics compared to their conventional counterparts. However, their consumption in European Union countries such as Spain remains limited. This paper develops a model based on the theory of planned behavior to explain the behavioral intention (BI) to use GMF, considering perceived value (PV), perceived usefulness (PU), perceived risk (PR), food neophobia (NPH), social influence (SI), gender, and age. Subsequently, it is tested in a sample of zoomers (members of Generation Z) and millennials (members of the Generation Y). Structural equation modeling reveals that PV, PU, SI, and belonging to Generation Z (GENZ) have a significantly positive influence on BI, while PR has a negative impact. Additionally, quantile regressions confirm that PU and SI are the most influential variables, as they maintain a consistent positive impact in the analyzed quantiles. The influence of PV, PR, and GENZ also remained consistent in sign in all quantile regressions. However, while PV and PR showed significant coefficients in most percentiles, GENZ was significant only at the extremes of the BI range. In a nutshell, PU and SI are the strongest positive predictors of behavioral intention, while PR acts as a consistent deterrent. Members of generation Z show higher predisposition toward GMF acceptance, particularly at the extremes of BI. The results of the analysis have various practical implications for the successful implementation of GMF, which are discussed in this study.

https://www.sciencedirect.com/science/article/pii/S2949824425002071

Dudeja, C.; Mishra, A.; Ali,A.; Singh, P.P.; Jaiswal, A.K. (2025): Microbial Genome Editing with CRISPR–Cas9: Recent

Advances and Emerging. Applications Across Sectors.  Fermentation 2025, 11, 410   https://doi.org/10.3390/fermentation11070410

CRISPR technology, which is derived from the bacterial adaptive immune system, has transformed traditional genetic engineering techniques, made strain engineering significantly easier, and become a very versatile genome editing system that allows for precise, programmable modifications to a wide range of microbial genomes. The economies of fermentation-based manufacturing are changing because of its quick acceptance in both academic and industry labs. CRISPR processes have been used to modify industrially significant bacteria, including the lactic acid producers, Clostridium spp., Escherichia coli, and Corynebacterium glutamicum, in order to increase the yields of bioethanol, butanol, succinic acid, acetone, and polyhydroxyalkanoate precursors. CRISPR-mediated promoter engineering and single-step multiplex editing have improved inhibitor tolerance, raised ethanol titers, and allowed for the de novo synthesis of terpenoids, flavonoids, and recombinant vaccines in yeasts, especially Saccharomyces cerevisiae and emerging non-conventional species. While enzyme and biopharmaceutical manufacturing use CRISPR for quick strain optimization and glyco-engineering, food and beverage fermentations benefit from starter-culture customization for aroma, texture, and probiotic functionality. Off-target effects, cytotoxicity linked to Cas9, inefficient delivery in specific microorganisms, and regulatory ambiguities in commercial fermentation settings are some of the main challenges. This review provides an industry-specific summary of CRISPR–Cas9 applications in microbial fermentation and highlights technical developments, persisting challenges, and industrial advancements.

https://www.mdpi.com/2311-5637/11/7/410

EFSA

FEZ Panel (2025): Safety evaluation of the food enzymeα-amylase from the genetically modified Bacillus licheniformis strain

DP-Dzb105. EFSA Journal, 23(7), e9531. https://doi.org/10.2903/j.efsa.2025.9531

https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9531

FEZ Panel (2025): Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modified Komagataella phaffii

strain DSM 34125. EFSA Journal, 23(7), e9546. https://doi.org/10.2903/j.efsa.2025.9546

https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9546

FEZ Panel (2025): Safety evaluation of the food enzyme aminopeptidase Y from the genetically modified Trichoderma reesei strain

DP-Nyf80. EFSA Journal, 23(7), e9560. https://doi.org/10.2903/j.efsa.2025.9560

https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9560

FEZ Panel (2025): Safety evaluation of the food enzyme asparaginase from the non-genetically modified Saccharomyces cerevisiae

strain ARY-1. EFSA Journal, 23(7), e9533. https://doi.org/10.2903/j.efsa.2025.9533

https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9533

EFSA (2025): Anastassiadou M, Mst Akhter T, Brocca D, Greco L, Josheski M, Lopez Romano M, Magrans JO, Romac A, Santos M and

Tauriainen T, 2025. Findings of not authorised substances in organic production. EFSA supporting publication 2025: 22(7): EN-9524. 579 pp. doi: 10.2903/sp.efsa.2025.EN-9524

https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/sp.efsa.2025.EN-9524